VD-T II (25-OH-Vitamin D Total)

Double antibody sandwich method facilitates accurate detection

Applications

Vitamin D plays an important role in maintaining calcium and phosphorus homeostasis. Vitamin D deficiency may lead to skeletal problems such as rickets, osteomalacia, progressive bone loss, and osteoporosis?^[1]. It may also lead to cancer, autoimmune diseases, and cardiovascular diseases?^[2]. Thus, it is of great significance to assess the nutritional status of vitamin D in the human body on time and achieve individualized vitamin D supplementation.

According to the American Endocrine Society's clinical practice guidelines^[3], "vitamin D insufficiency" is defined as 25-OH Vitamin D <30 ng/mL.

Currently, vitamin D insufficiency and deficiency are common problem worldwide. According to the study, more than 60% of people are deficient in vitamin D in the world ^[4], pregnant women, infants, children, elderly and obese people are especially at high risk of vitamin D deficiency.

25-OH-Vitamin D Detection Method

Mindray VD-T II Product Features

Performance

Traceability

EQA

Mindray VD-T lI reagents are traceable to the ID-LC/MS/MS reference method calibrated by SRM 2972, ensuring accurate results while providing a basis for comparability of measurements between systems.

Mindray's VD-Tll reagent has passed the CDC VDSCP program and participated in the DEQAS program with excellent results.

The double antibody sandwich detection improves the sensitivity and precision of the reagent

Mindray VD-ll test results are highly consistent with the ID-LC/MS/MS

Performance of Mindray VD-T II

Precision

Long-term quality control

Accuracy

Endogenous interferences

Drugs interferences

Mindray VD-Tll linearity range 3.00-150.00 ng/ml

Product information

Specifications of Mindray VD-T II

Specifcations of Mindray VD-T II

References:

[1] Passeri G, et al. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab 2003;88:5109-5115.

[2] Souberbielle JC et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice.Autoimmunity Reviews 2010; 9: 709- 715.

[3] Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P.Heaney, M. Hassan Murad, Connie M. Weaver, Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 96, lssue7,1 July 2011, Pages 1911-1930

[4] Martin,Rosas-Peralta,Michael,et al.Dysfunctional immunometabolic effects of vitamin D deficiency, increased cardiometabolic risk, Potential epidemiological alert in America?[J].Endocrinologia Diabetes Y Nutrici��n, 2017.DO1:10.1016/i.endien.2017.04.006.